计亮年科研成就科研综述计亮年系统地研究了钌等小分子配合物的组成和结构与DNA的作用及其机理在合成大量小分子配合物的基础上，用热力学、动力学及理论计算（密度泛函法）等总结了这些配合物的不同组成、结构与DNA的作用规律

总结了配合物主配体平面面积等多种因素对配合物和DNA作用方式和稳定性的影响，并进一步提出了许多具有应用前景的体系

在具有酶功能的新型配合物的合成及金属模拟酶的结构、性能及应用的研究方面，设计合成了金属多吡啶、金属卟啉及金属大环三个体系共数百余种新型配合物

 主要论著截至2016年11月，计亮发表了SCI收录的研究论文约600篇，这些论文被他人引用超过5000次

主编著作3部

 (1) Feng Gao, Hui Chao, Feng Zhou, Xin Chen, Yuan-Fang Wei, Liang-Nian Ji；Synthesis, GC selective DNA binding and topoisomerase II inhibition activities of ruthenium(II) polypyridyl complex containing 11-aminopteridino[6,7-f][1,10]phenanthrolin-13(12H)-one. [J]. Inorg. Biochem., 102, 1050-1059, 2008.(2) Lan-Mei Chen, Jie Liu, Jin-Can Chen, Cai-Ping Tan, Shuo Shi, Kang-Cheng Zheng and Liang-Nian Ji; Synthesis, characterization, DNA-binding and spectral properties of complexes [Ru(L)4(dppz)]2+ (L = Im and MeIm). [J]. Inorg. Biochem.,102 (2), 330-341, 2008.(3) Caiping Tan, Jie Liu, HongLi, Wenjie Zheng, Shuo Shi, Lanmei Chen, Liangnian Ji; Differences in structure, physiological stability, electrochemistry, cytotoxicity, DNA and protein binding properties between two Ru (III) complexes. [J]. Inorg. Biochem., 102, 347-358, 2008.(4) Lian-Cai Xu, Shuo Shi, Jun Li, Si-Yan Liao, Kang-Cheng Zheng and Liang-Nian Ji; A combined computational and experimental study on DNA-photocleavage of Ru(Ⅱ) polpyridyl complexes [Ru(bpy)2(L)]2+ (L=pip,o-mopip and p-mopip).[J]. C. S. Dalton. Trans., 291-301, 2008.(5) Bin Sun, Jing-Xin Guan, Li Xu, Bo-Le Yu, Long Jiang, Jun-Feng Kou, Li Wang, Xi-Dong Ding, Hui Chao, Liang-Nian Ji; DNA Condensation Induced by Ruthenium(II) Polypyridyl Complexes [Ru(bpy)2(PIPSH)]2+ and [Ru(bpy)2(PIPNH)]2+.[J]. Inorg. Chem., 48 (11), 4637-4639, 2009.(6) Feng Gao, Xing Chen, Jin-Quan Wang, Yu Chen, Hui Chao, Ji Liang-Nian; In Vitro Transcription Inhibition by Ruthenium(II) Polypyridyl Complexes with Electropositive Ancillary Ligands.[J]. Inorg. Chem., 48 (13), 5599-5601, 2009.(7) Hui-Juan Yu, Shu-Mei Huang, Lv-Ying Li, Hai-Na Jia, Hui Chao, Zong-Wan Mao, Jian-Zhong Liu, Liang-Nian Ji; Synthesis, DNA-binding and photocleavage studies of ruthenium complexes [Ru(bpy)2(mitatp)]2+ and [Ru(bpy)2(nitatp)]2+. [J]. Inorg. Biochem., 103 (6), 881-890, 2009.(8) Xing Chen, Feng Gao, Zhu-Xin Zhou, Wei-Yan Yang, Li-Tian Guo, Liang-Nian Ji; Effect of ancillary ligands on the topoisomerases Ⅱand transcription inhibition activity of polypyridyl ruthenium(Ⅱ) complexes.[J]. Inorg. Biochem., 104 (5), 576-582, 2010.(9) Jing Sun, Yan An, Li Zhang, Huo-yan Chen, Yan Han, Yu-jia Wang, Zong-wan Mao , Liang-nian Ji. Studies on synthesis, characterization, and G-quadruplex binding of Ru(II) complexes containing two dppz ligands.[J]. Inorg. Biochem., 105 (2), 149-154, 2011.(10) Feng Gao, Xing Chen, Qian Sun, Jia-Ning Cao, Jin-Qiang, Lin Qi-Zhi Xian, Liang-Nian Ji; Boosting the sensitivity of pH responsible luminescent switches of polypyridyl ruthenium(II) complexes by structural design.[J]. Inorg. Chem. Commun., 16, 25-27, 2012. 学术交流截至2016年11月，计亮年应邀在生物无机化学相关重要国际会议上作特邀报告、大会报告、重要报告和邀请报告30多次

 发明专利截至2016年11月，计亮年获批准和公开发明专利16项

 科研成果奖励获奖时间获奖项目获奖等级1978年全国科学大会奖 2012年3月金属酶模型化合物的结构、生物功能和作用机制研究广东省科学技术奖励一等奖 

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